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MANUKA HONEY ANTI-CANCER POTENTIAL

The anti-cancer potential of Manuka honey has been recognized by previous researchers and it is one of the benefits attributed to the product.

properties of manuka honey

Manuka honey peptides modified with MGO appeared to be able to inhibit HDAC a target for cancer treatment and modulation of gene expression and anti-inflammatory activity.

As the Manuka colloidal nanoparticles are anti-inflammatory due to their ability to inhibit phagocytosis, one potential anti-cancer attribute of the colliodal particles in Manuka honey is directly related to the modulation of inflammatory cells that are controlled by cancer cells in an orchestrated manner to promote the growth of the cancer. By switching off inflammation the cancer cells are able to recruit the white blood cells to do their bidding.

Another anti-cancer attribute of Manuka honey is directly related to the radical chemistry that is produced by photo-Fenton biochemistry. The thermogenesis that occurs from decoupling the mitochondria via radical generation of superoxide anion which gets converted to H2O2 by SOD allows light driven photo-reduction of iron and hydroxyl radical generation which is critical for apoptosis (pre-programmed cell death). Driving these processes in cancer cells that have no functional mitochondria and therefore resistant to apoptosis (Warburg effect), however, uptake of the colliodal particle into the cancer cell leads to exposure to H2O2 via NADPH oxidase in the phagosome, generating hydroxyl radicals and leading to apoptotic destruction of the cancer cell. 

It is known that thermogenesis induced by Manuka honey impacts on cancer cell survival. Elevated temperatures destroys cancer cells because of their membrane fluidity which is different from normal cells.

oxidative burst

The presence of methylglyoxal in Manuka honey generates radicals via chemical reactions with Cys, Lys and Arg. One of the derivatives CEL is produced through the reaction between methylglyoxal and lysine and this reaction can produce a CEL adduct. This modification looks similar to an acetyl lysine, which is a substrate for a HDAC enzyme. Evaluating the HDAC inhibitory properties of Manuka honey colloidal nanoparticles was performed and they were confirmed as having HDAC inhibitory properties.   

 

MGO modified lysine residues look like the HDAC substrate, which is why it is a HDAC inhibitor.

Manuka honey inhibition of HDAC

Dose response inhibition of Manuka honey inhibition of HDAC.

 Colloid literature in honey

Colloids were discovered in 1930's

honey colloids

 More colloid data. Proteins from the bees made from royal jelly. Transformational physics. Bee alchemical transformation of light into matter.

Isolated colloidal particles from honey. OH BEE HAVE 1 billion colloidal nanoparticles per mL.

Colloidal analysis Qnano (IZON)

Colloidal analysis usingn qNano by Izon 

 

Colloid seen in Manuka honey under the Evos FL microscope.